Saya was just a normal high school girl until the fateful day she was attacked by the chiropteran, bat-like beasts that feed off human blood. From that day forward, she begins a quest to rid the world of chiropteran and discover her true identity.

Blood+ One Night Kiss is an action adventure game set after episode seven of the animated series. Join Saya, Hagi, and a new companion Aoyama, as they try to save the town of Shiki from the chiropteran horde!